Ngaba uyasebenza kwintsimi yophando lwe-biomedical? Ukuba kunjalo, ke ngoko uziva nge-Sulfo-nhs. Njengoko indima ebalulekileyo yale nqaku kuphando iyaqhubeka iqaphela, le postit ingena kwiilebhu ezininzi kwihlabathi liphela. Kweli nqaku, sixubusha ngantoni iSulfo-NHs kwaye kutheni eso sisixhobo esixabisekileyo sabo bafunda isayensi yebhayoloji.
Okokuqala, yintoni i-silfo-nhs? Igama lingumoya kade ovuthuzayo, ke ngoko makhe siyikhuphe. USulfo umela i-Sulfoni scid kwaye i-NHS imele i-N-hydroxyussuccimimiimimiimimiimilam. Xa la manqaku mabini adibanisa,Sulfo-NHsiveliswa. Le computha isebenzisa izibonelelo ezininzi kuPhando lwe-biomedical, kodwa enye yeepropathi zayo eziphambili kukukwazi ukukhetha iileyili proteriins.
I-Sulfo-NHS isebenza ngokuphendula ngee-meines eziphambili (ie -NH2) kumakhonkco asecaleni kwe-lysine intsali. Eyona nto ibalulekileyo, i-Sulfo-NHS ye-protens ", ibenza lula ukuba zichonge kwaye zihlalutye ngeentlobo ezahlukeneyo zovavanyo. Oku kubangele ukuba iindawo ezininzi zophando zophando zikwazi ukuqhubela phambili ngokuchaneka okukhulu kunye namanqanaba aphezulu.
Ke, yintoni iSulfo-NHS esetyenziselwa ntoni? Ukusetyenziswa kwesiqhelo kwale nqaku kukuvela kuvavanyo oluvunyiweyo. I-Sulfo-NHS ibonisiwe kwii-antibodies ze-antibodies kunye nee-antigens, ukuvula iindlela ezintsha zokufunda ukungathobeli kunye nezifo. Ukongeza,Sulfo-NHsIngasetyenziswa kwizifundo zeprotein-protein protein yeprotein njengoko ivumela abaphandi ukuba babone ngokulula xa kusebenzisana kuzo ezimbini.
Enye indawo apho i-Sulfo-NHS isetyenziswa kakhulu yile yokuphikisana. Iproteokis kufunda ulwakhiwo kunye nomsebenzi wazo zonke iiproteni kwilungu lezinto, kwayeSulfo-NHssisixhobo esiphambili kolu hlalutyo. Ngokumakisha iiproteni nge-Sulfo-NHS, abaphandi banokwenza uvavanyo lokufumana ulwazi oluneenkcukacha malunga ne-protem yento enikiweyo, enokuthi incede ichonge abantu abamasmaki abanokubakho.
I-Sulfo-NHS ikwadlala indima ekuphuhlisweni kwamayeza amatsha. Xa abaphandi bazama ukuphuhlisa ichiza elitsha, kubalulekile ukuba uqiniseke ukuba ijolise kwiprotein ecetywayo kwaye hayi enye iproteyini emzimbeni. NgokusebenzisaSulfo-NHsUkukhetha ngokukhethekileyo iiproteni, abaphandi banokuchonga iithagethi ezichanekileyo zeziyobisi ezinokubakho, ezinokunceda ukukhawulezisa inkqubo yophuhliso lweziyobisi.
Ke unakho! I-Sulfo-NHS isenokungabi yigama elaziwa ngaphandle koluntu lwesayensi, kodwa le computha ikhawuleza iba sisixhobo esixabisekileyo kuphando lwe-biodimed. Ukusuka kwi-Imamogy yoPhando kwiProtetics kwiZiyobisi, i-Sulfo-NHS inceda abaphandi benza inkqubela phambili kwezi ndawo kwaye sonwabile ukubona ukuba yeyiphi na into efumanekayo.
IXESHA LOKUQALA: Jun-12 ukuya ku-2023