I-Alkynes ikhona ngokubanzi kwiimveliso zendalo, ii-molecule ezisebenzayo ze-biologically kunye nezinto ezisebenzayo eziphilayo.Kwangaxeshanye, zikwabalulekile kwi-organic synthesis kwaye zinokungena kwiinguqu ezininzi zeekhemikhali.Ke ngoko, ukuphuhliswa kweendlela ezilula nezisebenzayo zokwakha iialkynes zingxamisekile kwaye ziyafuneka.Nangona impendulo ye-Sonogashira eyenziwa yintsimbi yenguqu yenye yezona ndlela zisebenzayo kwaye zilungele ukudibanisa i-aryl okanye i-alkenyl substituted alkynes, ukusabela kokudibanisa okubandakanya i-alkyl electrophiles engasetyenziswanga ngenxa yeempendulo zecala ezifana nokupheliswa kwe-bH.Isagcwele imiceli mngeni kunye nophando oluncinci, ubukhulu becala bukhawulelwe kwii-alkanes ze-halogenated ezingenabubele kunye nexabiso eliphezulu.Ke ngoko, ukuphononongwa kunye nokuphuhliswa kwe-Sonogashira yokusabela kwezinto ezintsha, ezingabizi kwaye zifumaneka ngokulula kwi-alkylation reagents ziya kuba zibaluleke kakhulu zombini kwi-laboratory synthesis kunye nezicelo zoshishino.Iqela lenze ngobuchule kwaye liphuhlise i-amide-type NN2 pincer ligand entsha, efumaneka lula kwaye izinzile, eyathi okokuqala yaqonda ukhetho olufanelekileyo kunye noluphezulu lwe-alkylamine derivatives kunye ne-alkynes ye-terminal enoluhlu olubanzi lwemithombo ye-nickel catalytic, ephantsi kwaye kulula ukuyenza. fumana.I-reaction cross-coupling reaction isetyenziswe ngempumelelo kwi-deamination kade kunye nokuguqulwa kwe-alkynylation yeemveliso zendalo ezintsonkothileyo kunye neemolekyuli zamachiza, ezibonisa ukusebenza kakuhle kokusabela kunye nokuhambelana kweqela elisebenzayo, kwaye ibonelela ngobutsha bokuhlanganiswa kwee-alkyne ezibalulekileyo ezifakwe endaweni ye-alkyl.Kunye neendlela ezisebenzayo.
Ixesha lokuposa: Nov-22-2021